vaccination, it is noted in the study that making general statements about vaccines causing deaths is not a valid medical practice. Vaccines save thousands of people from preventable human diseases each year and are one of the biggest strides of modern medicine. Despite this, many people are apprehensive about taking vaccines because of adverse side effects or fear of death or further harm—and these anxieties are not completely unfounded. For instance, an incident in 1955 called the “Cutter Incident” became known as “one of the worst pharmaceutical disasters in US history.’ A flaw in the Salk polio vaccine making process at Cutter Laboratories led to a production of what was originally thought to be an inactivated vaccine but ended up containing the actual disease it was supposed to prevent. As a result, in 40,000 cases of polio, 51 cases ended up with permanent paralysis and five deaths were recorded in vaccinated individuals. Another 113 cases of paralysis and five more deaths were noted among people with contact to those who were vaccinated. As big of a disaster as this was, this isolated incident was what pushed pharmaceutical companies and governments for more extensive testing, monitoring, and regulation for vaccines. Furthermore, while it is minimal, there is still a risk of death with some vaccines—namely the smallpox vaccine which based on historical data is about one death per million people receiving the first round of inoculations. This number decreases to one death per four million people receiving a second dose, according to the 2015 study. For the smallpox vaccine, deaths have also been known to happen among non-vaccinated people who have had contact with the vaccination site of a vaccinated person. Smallpox vaccinations of pregnant women can also increase the risk of fetal infection which causes stillbirths or infant death, according to the same study. While deaths and adverse side effects caused by vaccines are still incredibly rare, that is not to say that they don’t happen at all or that the issue should not be discussed. However, health care providers can decrease this risk by properly screening for precautions and with a 15-minute waiting period after patients receive a vaccine to reduce the risk of fall-related injuries or syncope. The establishment of The Vaccine Adverse Event Reporting System (VAERS) in 1990 allows people to report medical events following vaccines. The program has helped to identify Toh oLacxeM eM Ac1OUSM ANNA cele el) al ckomcTele aire owe amass are] | problem after the first rotavirus vaccine was introduced and other neurological and gastrointestinal diseases related to yellow fever. COVID VACCINES IN CANADA Despite the quick rollout of the COVID-19 vaccines, the testing and development phase of a vaccine is usually a long and arduous process. According to Wellcome Trust, a research-based charity from the UK, the research phase of a vaccine can take anywhere from two to five years and after that the vaccine is put through extensive testing phases. In total, a vaccine can take up to 10 years to fully develop and cost up to $500 million. Amazingly, the COVID-19 vaccine was developed in less than a year with trials starting in April 2020 for the Pfizer vaccine and later in July for the Moderna vaccine. However, the effects on pregnant and breastfeeding women are unknown as those groups were left out of the clinical trials. The small testing period with this vaccine compared to other vaccines has given many people cause for trepidation when it comes to receiving the COVID-19 vaccine. According to a survey of 2002 Canadians by KPMG, 8 CC out of 10 Canadians said they would line up to get the vaccine, but only about 50 percent said they feel safe taking it. A quarter of them worry it is not safe but are willing to take the risk to get the economy, and their lives back on track. Health authorities say the benefits outweigh the risks of this vaccine, and Health Canada has weekly reports on the adverse effects of the vaccine with five “serious” reactions out of more than 115,000 administered doses (as of January 1). The first limited round of vaccinations came to Canada in December of 2020 with health care workers being the first to receive the inoculations. “Between the early doses we have already received, and the shipments now scheduled, we're on track to have at least 1.2-million doses from both Pfizer and Moderna delivered by January 31,’ PM Justin Trudeau said in a CBC article. Canada has secured contracts with Pfizer BioNTech for 20-million doses and 40-million doses for Moderna by the end of 2021. MODERNA VS PFIZER So, if you are part of the population that decides you want to take the vaccine, all that’s left is to decide which one to take. What's the real difference between the two? Health Canada authorized Moderna as a vaccine after analyzing the phase three trial results which tested the vaccine on 30,000 people in the US. Half of the study group received the vaccine while the other half received a placebo and was found to be 9411 percent effective in participants with no prior exposure to COVID-19 and nearly 87 percent effective in people over 65 years old. Although, Health Canada warns people to make sure they are not allergic to ingredients before taking the vaccine and does not recommend it for people who currently have symptoms of the virus. Both vaccines work by using mRNA technology which directs cells to produce proteins triggering an immune response to prevent or fight the virus, and both require two doses—a primer and a booster shot—taken a month apart. The Pfizer vaccine is for people as young as 16 years old has shown to be about 95 percent efficient at preventing symptomatic COVID-19 infection while Moderna, for people 18 and up, sits at 94.1 percent effective and effectiveness is lowered when the person receiving the vaccine is over 65. It is still unclear whether the vaccines prevent asymptomatic infection or if vaccinated people can still transmit the virus if they are infected but show no symptoms. Pfizer contains 30 micrograms of the vaccine while Moderna is 100 micrograms, meaning it is more potent per dose, yet less effective than Pfizer. Pfizer has also been under scrutiny lately as allergic reactions have been reported with the vaccine that were not seen during the clinal trial phase. Furthermore, in Norway, the medicines agency has reported that 29 people have suffered side effects such as fever or frailness resulting in 13 deaths. All of the deaths were with people over 80 and living in care homes. Vaccines are extensively tested to ensure safety for people who take them. Of course, with a smaller testing period compared to other vaccines (10 years compared to less than a year) it's no surprise that people are feeling hesitant about taking the COVID-19 vaccine. As of now, it is unclear what the long-term effects of the COVID-19 vaccines could be since it’s only been in use for less than a year. However, health authorities tell us that the short-term effect is inoculation towards the coronavirus. If someone does decide they should take it, caution should be taken by those who are pregnant or breastfeeding, currently have COVID-19 symptoms, or those who are allergic to the vaccine's ingredients. The effects on pregnant and breastfeeding women are unknown as those groups were left out of the clinical trials.